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Evidence of sex difference in dopaminergic modulation of serum thyroid stimulating hormone secretion in primary hypo thyroidism


, : Evidence of sex difference in dopaminergic modulation of serum thyroid stimulating hormone secretion in primary hypo thyroidism. Endocrinologia Japonica 28(2): 127-132

Sex difference with respect to the dopaminergic modulation of serum TSH [thyroid stimulating hormone] secretion in patients with primary hypothyroidism was demonstrated. Ten patients, 4 men and 6 women, with hypothyroidism were given 10 mg of domperidone (Domp) i.v., a very potent and specific dopamine receptor blocking agent, which could not readily cross the blood brain barrier. There was a significant rise in the TSH level after Domp i.v. in female patients with primary hypothyroidism, from basal values at 0 time of 74.4 .+-. 33.8 (mean .+-. SE) .mu. .mu.U/ml to 171.2 .+-. 94.9 at 30 min (P < 0.001), 159.6 .+-. 100.5 at 60 min (P < 0.001). No significant change in serum TSH values after Domp i.v. occurred in male patients with primary hypothyroidism, from basal values at 0 time of 181.1 .+-. 39.9 .mu.U/ml to 171.4 .+-. 31.1 at 30 min, 180.7 .+-. 33.2 at 60 min and 172.7 .+-. 31.0 at 90 min. After thyroid hormone therapy, max .DELTA. TSH values and the change from basal to peak values were significantly related to basal TSH values in female patients with primary hypothyroidism (r = + 0.93, P < 0.001), while max .DELTA. TSH in male patients was inversely related to basal TSH values within the limited concentrations (r = -0.78, P < 0.02). Maximum TSH responses to i.v. administration of Domp in male and female hypothyroid patients were observed in different basal TSH values, i.e., < 100 .mu.U/ml in males and > 100 .mu.U/ml in females.

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