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Evidence of specific receptors for gastric inhibitory poly peptide


Comptes Rendus des Seances de l'Academie des Sciences Serie III Sciences de la Vie 297(12): 563-566
Evidence of specific receptors for gastric inhibitory poly peptide
Receptors for gastric inhibitory polypeptide (GIP) were characterized in particles enriched from plasma membranes obtained from a transplantable hamster insulinoma. Native GIP, at concentrations between 10-10-10-6 M, competitively inhibited the binding of 125I-GIP to membranes. The binding was highly specific since, among the peptides tested, only the porcine peptide having N-terminal histidine and C-terminal isoleucine amide (PHI), at high concentration (10-6 M), inhibited by 17% the binding of 125I-GIP. The existence of these receptors suggested that GIP could act directly on .beta.-cells.


Accession: 005411736



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