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Evidence of sympathetic involvement with normal parasympathetic innervation in diabetes mellitus


Medicina Clinica 85(19): 789-791
Evidence of sympathetic involvement with normal parasympathetic innervation in diabetes mellitus
The incidence of autonomic sympathetic neuropathy has been studied in 49 diabetic patients with unimpaired autonomic parasympathetic function (RR ratio higher than 1.10 after expiration, inspiration, orthostatic position, handgrip test and Valsalva manoeuvre). 53% of patients (n = 26) showed an impaired response of arterial pressure to orthostatic position and 16% had and abnormal regulation of arterial pressure, with a decrease in mean arterial pressure higher than 20 mm Hg one minute after orthostatic position. These patients show a higher incidence and severity of ocular microvascular complications. Isolated autonomic sympathetic neuropathy may be an early sign of unfavourable evolution in diabetic microangiopathy.


Accession: 005411758

PMID: 4094499



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