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Evidence of the existence of a factor that induces complement c 3 receptors on bone marrow cells


Blood 61(2): 403-407
Evidence of the existence of a factor that induces complement c 3 receptors on bone marrow cells
The existence of a molecule responsible for the induction of complement C3R receptors (C3R) on murine bone marrow cells (C3R inducer, C3RI) is demonstrated in lung conditioned media. The inducer of Fc receptors on murine bone marrow cells (FcRI) and the colony-forming factor MGI (macrophage and granulocyte inducer) are also identified from the same source. The 3 inducing factors are shown by molecular sieving chromatography and by isoelectric focusing in granulated gel to be 3 different molecules. The MW estimated were of 35,000, 22,000 and 10,500 for C3RI, MGI and FcRI, respectively, with isoelectric pH values of 3.9, 6.6 and 7.6 for the same molecules. The C3RI is assumed to be of protein nature, because the molecule lost its biologic activity after trypsin or heat treatment. In the 2 techniques used, the 3 peaks of activity were completely separated, suggesting that the induction of C3 or Fc receptors and colony formation are mediated by different molecules, and thus regulated independently at the cellular level.


Accession: 005411774



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