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Evidence of trh and trh binding sites in human nonsecreting pituitary adenomas


, : Evidence of trh and trh binding sites in human nonsecreting pituitary adenomas. Journal of Clinical Endocrinology & Metabolism 65(5): 1014-1019

Immunoreactive TRH (IR-TRH) and TRH-binding sites were sought in nonsecreting pituitary adenomas. [3H]TRH bound specifically to cellular membranes from 11 of 12 such adenomas studied with a dissociation constant (Kd) of 50 .+-. 5 (.+-. SEM) nmol/L and a maximum number of binding sites of 76 .+-. 16 fmol/mg membrane protein (range, 32-229 fmol/mg protein). IR-TRH was detected in all 8 of the tumors in which it was sought. The identity of the IR-TRH WAS verified by high pressure liquid chromatography. The tumor IR-TRH concentration varied from 45-248 fmol/mg cell protein (mean, 109 .+-. 28 fmol/mg cell protein), about half that in normal human pituitary (229 .+-. 55 fmol/mg protein). There was no correlation between the number of binding sites and the IR-TRH content. The role of TRH in nonsecreting pituitary adenomas is unknown at this time.

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