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Evidence on the retrograde neurotoxicity of doxorubicin

, : Evidence on the retrograde neurotoxicity of doxorubicin. Neuroscience Letters 53(2): 215-220

Doxorubicin, a fluorescent retrograde neurotoxin, killed neurons in the ventral tegmentum and thalamus that were afferent to the injection site in the caudate-putamen in rats. The neurotoxic effects in the ventral tegmentum and thalamus were prevented by a large coronal knife cut caudal to the injection site in the striatum, suggesting that retrograde transport of doxorubicin is necessary for the death of afferent neurons. In the striatum the neurotoxic effects of doxorubicin 14 days post-injection were quantitatively much greater on afferent neurons (as assessed by a 72% drop in dopamine levels) than on local striatal perikarya (as evidenced by the small 22% drop in the activity of glutamic acid decarboxylase). Doxorubicin may be a useful tool for selectively destroying, by way of retrograde transport, neurons that are afferent to a site in the brain.

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Accession: 005411868

PMID: 2580250

DOI: 10.1016/0304-3940(85)90188-0

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Other references

Ravitch, M.M., 1969: Primam non nocere. Medical Times 97(10): 252-254

Bastid, C.; Azar, C.; Doyer, M.; Sahel, J., 1994: Percutaneous treatment of hydatid cysts under sonographic guidance. Nine patients (five males, four females) with 14 hydatid cysts were treated with albendazole and percutaneous drainage under sonographic guidance. All but two cysts were hepatic. The average cyst diameter was 81.5 mm (range: 42-180 mm). There were...

Fowler J.W.; Shirley J., 1947: A method of making thin sections from friable materials and its use in the examination of shales from the Coal Measures. Describes a procedure for using the thermoplastic resin Santolite in the preparation of friable and water-soluble sediments as thin sections.

Robe, W.E.; Griffiths, H., 1994: The impact of NO-3-loading on the freshwater macrophyte Littorella uniflora. Journal of Experimental Botany 45(SUPPL ): 55

Chang, C., 2016: Q&A: How do plants respond to ethylene and what is its importance?. Ethylene gas is a major plant hormone that influences diverse processes in plant growth, development and stress responses throughout the plant life cycle. Responses to ethylene, such as fruit ripening, are significant to agriculture. The core mole...

SCHNEEGANS.E.; HEUMANN.G.; ISC.T.EUSSARD.C.; LEV.S.LAGY.J., 1964: The Course Of Nonrachitic Tetany Of Neonatal Onset. Archives Francaises de Pediatrie 21: 250-260

Toivari, L.; Lindquist, O., 1961: The Marsh Warbler (Acrocephalus palustris) and Blyth's Reed Warbler (Acrocephalus dumetorum) in the district of Lappeenranta, Summer 1960. Ornis Fennica, 38: 93-95

Hvistendahl, M., 2011: Young and restless can be a volatile mix. Science 333(6042): 552-554

Huizar, J.F.; Awasthi, A.; Kozman, H., 2006: Fibromuscular dysplasia and acute myocardial infarction: evidence for a unique clinical and angiographic pattern. Fibromuscular dysplasia (FMD) is a noninflammatory, nonatherosclerotic disease of the small- to medium-sized vessels that primarily affects young females in their second to fourth decades of life. Typically, FMD involves the renal and extracranial...

Kott, P., 1951: Corella halli n. sp., a new ascidian from the English Channel. Journal of the Marine Biological Association of the United Kingdom, 30: 33-36