+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evidence on the retrograde neurotoxicity of doxorubicin

Neuroscience Letters 53(2): 215-220

Evidence on the retrograde neurotoxicity of doxorubicin

Doxorubicin, a fluorescent retrograde neurotoxin, killed neurons in the ventral tegmentum and thalamus that were afferent to the injection site in the caudate-putamen in rats. The neurotoxic effects in the ventral tegmentum and thalamus were prevented by a large coronal knife cut caudal to the injection site in the striatum, suggesting that retrograde transport of doxorubicin is necessary for the death of afferent neurons. In the striatum the neurotoxic effects of doxorubicin 14 days post-injection were quantitatively much greater on afferent neurons (as assessed by a 72% drop in dopamine levels) than on local striatal perikarya (as evidenced by the small 22% drop in the activity of glutamic acid decarboxylase). Doxorubicin may be a useful tool for selectively destroying, by way of retrograde transport, neurons that are afferent to a site in the brain.

Accession: 005411868

PMID: 2580250

DOI: 10.1016/0304-3940(85)90188-0

Download PDF Full Text: Evidence on the retrograde neurotoxicity of doxorubicin

Related references

Cyclo phosphamide and doxorubicin pharmaco kinetics in patients with sarcomas evidence for altered doxorubicin metabolism. Clinical Research 30(2): 423A, 1982

Mptp induced neurotoxicity anterograde or retrograde. Anatomical Record 223(4): 51A-52A, 1989

Doxorubicin induces biphasic neurotoxicity to rat cortical neurons. Neurotoxicology 29(2): 286-293, 2008

Doxorubicin myotoxicity and neurotoxicity injection into the orbicularis oculi. Society for Neuroscience Abstracts 14(2): 1219, 1988

Doxorubicin-induced cardiac neurotoxicity Study by iodine-123 m-iodobenzylguanidine. European Heart Journal 14(ABSTR SUPPL ): 339, 1993

Early and delayed neurotoxicity of mitoxantrone an doxorubicin following subarachnoid injection. Journal of Neuro-Oncology 6(2): 135-140, 1988

Doxorubicin fluorescent retrograde neuro toxin. Anatomical Record 202(3): 100A-101A, 1982

Doxorubicin-induced cardiac neurotoxicity: study with iodine 123-labeled metaiodobenzylguanidine scintigraphy. Journal of Nuclear Cardiology 3(1): 37-41, 1996

Neurotoxicity of adriamycin (doxorubicin) perfused through the cerebrospinal fluid spaces of the rhesus monkey. Toxicology and Applied Pharmacology 44(1): 191-205, 1978

I-123-metaiodobenzylguanidine scintigraphy may detect doxorubicin-induced cardiac neurotoxicity before deterioration of LV function. Circulation 92(8 SUPPL ): I471, 1995