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Evidence suggesting that di methyl imipramine induced resistance to extinction is not mediated by the dorsal noradrenergic bundle


, : Evidence suggesting that di methyl imipramine induced resistance to extinction is not mediated by the dorsal noradrenergic bundle. Brain Research 238(1): 251-253

Rats were trained to press a lever for food rewards, then given a 5-wk break, followed by a single extinction session. Animals which received 14 daily desmethylimipramine (DMI) [a tricyclic antidepressant] injections, ending 4 days before the extinction session, showed resistance to extinction; no effect was seen in animals which received DMI during acquisition. The opposite pattern of results would be predicted if the effect were mediated by changes in the efficacy of the dorsal noradrenergic bundle.

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