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Evidence suggesting that di methyl imipramine induced resistance to extinction is not mediated by the dorsal noradrenergic bundle


, : Evidence suggesting that di methyl imipramine induced resistance to extinction is not mediated by the dorsal noradrenergic bundle. Brain Research 238(1): 251-253

Rats were trained to press a lever for food rewards, then given a 5-wk break, followed by a single extinction session. Animals which received 14 daily desmethylimipramine (DMI) [a tricyclic antidepressant] injections, ending 4 days before the extinction session, showed resistance to extinction; no effect was seen in animals which received DMI during acquisition. The opposite pattern of results would be predicted if the effect were mediated by changes in the efficacy of the dorsal noradrenergic bundle.


Accession: 005411900

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Related references

Willner, P.; Towell, A., 1982: Evidence suggesting that DMI-induced resistance to extinction is not mediated by the dorsal noradrenergic bundle. Rats were trained to press a lever for food rewards, then given a 5 week break, followed by a single extinction session. Animals which received 14 daily desmethylimipramine (DMI) injections, ending 4 days before the extinction session, showed resi...

Mason, S.T.; Iversen, S.D., 1978: The dorsal noradrenergic bundle extinction and nonreward. Lesion to the dorsal noradrenergic bundle using 6-hydroxydopamine [6-OHDA] produces resistance to extinction which might be due to an inability to code for non-reward. 6-Hydroxydopamine lesioned rats were tested on a double fixed interval (FI) sch...

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Tombaugh T.N.; Pappas B.A.; Roberts D.C.S.; Vickers G.J.; Szostak C., 1983: Failure to replicate the dorsal bundle extinction effect telencephalic norepinephrine depletion does not reliably increase resistance to extinction but does augment gustatory neophobia. Depletion of telencephalic noradrenaline [norepinephrine, NE], caused by lesion of the dorsal tegmental bundle, increases persistence of non-reinforced responding in various operant tasks; this effect is referred to as the dorsal bundle extinction...

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