EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evidence that 2 mutations w dzl and z 1 affecting synapsis dependent genetic behavior of white are transcriptional regulatory mutations


Cell 40(4): 819-826
Evidence that 2 mutations w dzl and z 1 affecting synapsis dependent genetic behavior of white are transcriptional regulatory mutations
Both the white mutant allele, wDZL, and the zeste mutant allele, z1, reduce white transcript levels in adult head tissues, but have no effect on these levels in other tested adult tissues. wDZL results from insertion of a complex transposon .apprx. 5.0 kb [kilobase] 5' to white. Juxtaposition of this transposon to white produces a novel transcription unit beginning in the transposon and producing a mature transcript containing both white and transposon sequences. Head-specific expression of this novel transcription unit correlates with the observed repression of wild-type white transcript levels. wDZL and z1 are known to cause synapsis-dependent repression of w+ expression in trans as assessed by eye pigment deposition. An unexpected and informative correspondence is suggested between cis and synapsis-dependent trans regulatory effects. The implied mechanistic relationship between regulation of transcription and transvection effects in Drosophila is discussed.


Accession: 005411951



Related references

Evidence that two mutations, wDZL and z1, affecting synapsis-dependent genetic behavior of white are transcriptional regulatory mutations. Cell 40(4): 819-825, 1985

Genetic and physical studies of a portion of the white locus participating in transcriptional regulation and in synapsis-dependent interactions in Drosophila adult tissues. Genetics 110(3): 479-494, 1985

Second-site mutations selected in transcriptional regulatory sequences compensate for engineered mutations in the vesicular stomatitis virus nucleocapsid protein. Journal of Virology 86(20): 11266-11275, 2012

Induction of mutations in trans acting regulatory genes affecting the white locus of drosophila. Genetics Part 2: S12, 1984

Mutations affecting the regulatory subunit of cyclic amp dependent protein kinase. Journal of Cellular Biochemistry Supplement (6): 120, 1982

Regulatory gene mutations affecting apolipoprotein gene expression: functions and regulatory behavior of known genes may guide future pharmacogenomic approaches to therapy. Clinical Chemistry and Laboratory Medicine 41(4): 411-424, 2003

NF1 mutation rather than individual genetic variability is the main determinant of the NF1-transcriptional profile of mutations affecting splicing. Human Mutation 27(11): 1104-1114, 2006

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans. Pharmacogenetics 10(5): 415-424, 2000

Synapsis dependent allelic complementation between decapentaplegic mutations of drosophila melanogaster. Genetics 97(1 SUPPL): S40, 1981

Genetic analysis of DNA replication in bacteria: dnaB mutations that suppress dnaC mutations and dnaQ mutations that suppress dnaE mutations in Salmonella typhimurium. Genetics 108(1): 25-38, 1984