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Evidence that 4 glutamic acid neurotensin is the naturally occurring neurotensin in plasma


Peptides (New York) 4(4): 543-548
Evidence that 4 glutamic acid neurotensin is the naturally occurring neurotensin in plasma
Neurotensin (NT) is a tridecapeptide (< Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH). Apparently, the naturally occurring neurotensin is (Gln4)-NT and it can be hydrolyzed to (Glu4)-NT during extraction. It was determined whether the neurotensin found in human and rat plasma after fat ingestion is (Gln4)-NT or (Glu4)-NT. Two neurotensin antisera are described that have high avidity for (Glu4)-NT but low avidity for (Gln4)-NT. (Gln4)-NT could be separated from (Glu4)-NT by ion-exchange chromatography. The plasma samples were analyzed without prior extraction to avoid hydrolysis of the naturally occurring peptide. Neurotensin in unextracted human and rat plasma is present as (Glu4)-NT, as originally proposed by Carraway and Leeman.


Accession: 005411956



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