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Evidence that 5 hydroxy tryptamine agonist induced rotational behavior in the rat is mediated via 5 hydroxy tryptamine 2 receptors

, : Evidence that 5 hydroxy tryptamine agonist induced rotational behavior in the rat is mediated via 5 hydroxy tryptamine 2 receptors. Psychopharmacology 83(2): 163-166

The rotational behavior induced by 5-HT agonists was investigated in rats with lesions of the dorsal raphe' nucleus (DRN). 5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) caused dose-related contralateral rotation in rats with 5,7-dihydroxytryptamine (5,7-DHT) lesions of the DRN. Similar findings were presented for the 5-HT1 agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and 5-methoxy-3 (1,2,3,6-tetrahydropyridin-4-yl) (1H indole) (RU24969). In this model, in agreement with the behavioral studies, both agonists had a greater affinity for the 5-HT1 binding site when compared with the 5-HT2 binding site. Antagonist studies using selective 5-HT2 antagonists (ketanserin and pirenperone) at non-sedative doses failed to inhibit this behavior. The classical 5-HT antagonist methysergide caused significant inhibition of the rotational behavior. 5-HT agonist-induced rotation in the rat is apparently mediated via 5-HT1 receptors, probably located in the substantia nigra.

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