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Evidence that a behavioral augmentation following repeated amphetamine administration does not involve peripheral mechanisms


, : Evidence that a behavioral augmentation following repeated amphetamine administration does not involve peripheral mechanisms. Pharmacology Biochemistry & Behavior 17(3): 547-554

Repeated administration of amphetamine (AMPH) to rats results in an augmentation of the drug-induced locomotion and stereotypy. The potential role for some dispositional and peripheral sympathomimetic factors in mediating the enhanced stereotypy response was examined. These included 3 factors associated with repeated AMPH administration: the possible accumulation of AMPH in a peripheral mobilizable pool; repeated sympathetic activation; and AMPH metabolite-induced depletion of peripheral stores of norepinephrine. The approach utilized was to selectively reduce or mimic the peripheral actions of AMPH through the use of non-phamacological or pharmacological manipulations which are relatively lacking in AMPH-like central stimulant effects. Apparently, these factors cannot account for the augmentation of the behavioral response to AMPH. These behavioral alterations may reflect changes in the responsiveness of brain mechanisms which mediate the behavioral effects of the drug.

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Accession: 005411972

PMID: 6890688

DOI: 10.1016/0091-3057(82)90317-3

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