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Expected particle size distributions of crystals produced from nonisothermal recrystallization


Journal of Pharmaceutical Sciences 74(12): 1322-1326
Expected particle size distributions of crystals produced from nonisothermal recrystallization
It is shown, using oxalic acid dihydrate as a model, that nonisothermal recystallization of powders gives rise to particle size distributions which approach log-normality in many cases. The number of particles formed is, primarily, a function of the nucleation rate constants and the particle size distribution, i.e., the mean diameter and standard deviation are functions of the growth kinetic parameters.

Accession: 005419473

PMID: 4087200

DOI: 10.1002/jps.2600741214

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