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Experimental amoebiasis part 1 pathogenicity of axenically cultured entamoeba histolytica in the brain of the new born mouse



Experimental amoebiasis part 1 pathogenicity of axenically cultured entamoeba histolytica in the brain of the new born mouse



American Journal of Tropical Medicine and Hygiene 26(3): 393-401



Axenically cultured E. histolytica inoculated intracerebrally into newborn Swiss mice invaded the cerebrum and produced multiple abscesses containing viable trophozoites. As few as 20 amebae of a virulent strain (HM-1:IMSS) occasionally produced fatal disease, 200 killed about 75% of animals and higher doses regularly killed all animals. In contrast, avirulent strains (HK-9 and HB-301:NIH) failed to produce acute brain disease in comparable time periods even when mice were inoculated with as many as 20,000 amebae. Two other strains (1295 and H-458:CDC) were of intermediate virulence. High doses of avirulent amebae often produced hydrocephalus as a late manifestation. In newborn, 3-wk-old and 6-wk-old mice resistance to infection increased with age, and older animals often responded late to virulent strains by developing hydrocephalus.

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Accession: 005421263

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