Experimental and clinical study on atp magnesium chloride administration for post ischemic acute renal failure
Hirasawa, H.; Odaka, M.; Soeda, K.; Kobayashi, H.; Ohtake, Y.; Oda, S.; Kobayashi, S.; Sato, H.
Clinical and Experimental Dialysis and Apheresis 7(1-2): 37-48
ISSN/ISBN: 0276-5497 Accession: 005421596
The effect of ATP-MgCl2 on the recovery of renal function following renal ischemia was studied. Bilateral renal ischemia was produced for 90 min in dogs. Immediately after the release of ischemia, ATP-MgCl2 (50 .mu.moles/kg) was given i.v. Serum creatinine and FeNa [excreted fraction of filtered Na] were measured following the release of ischemia. Renal cellular energy charge, glomerular endothelial thickness and percent circularity of interstitial cells were measured. Creatinine and FeNa were significantly lower in ATP-MgCl2 treated dogs compared to those in saline treated controls. Changes in energy charge, glomerular endothelial thickness and percent circularity indicated ischemically induced renal cellular edema was reversed with ATP-MgCl2 through the improvement of energy metabolism. Taking those experimental data into consideration, ATP-MgCl2 was given to 16 acute renal failure patients and 13 patients survived. ATP-MgCl2 administration is effective for the treatment of acute renal failure.