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Experimental chemotherapy in mice infected with trichinella spiralis using levamisole and mebendazole



Experimental chemotherapy in mice infected with trichinella spiralis using levamisole and mebendazole



Japanese Journal of Parasitology 34(5): 315-324



Male, 6-week-old ICR mice were infected with 300 larvae of Trichinella spiralis in order to examine the anthelminthic efficacy of levamisole and mebendazole. Levamisole resolved in distilled water on mebendazole suspended in 0.01% cremophor EL was administered orally to each infected mouse by a stomach tube at a dose of 50 mg/kg once daily for 6 consecutive days. The treatments were performed during the intestinal, migratory and encysted phases of T. spiralis. The adult worms were recovered from small intestine by the Baermann funnel method and the larvae were recovered from skeletal muscle by digestion method. Both levamisole and mebendazole were highly effective against the adult worms. The reduction rates were 99.7% with levamisole and 98.3% with mebendazole. The female worms were more susceptible to mebendazole than the male worms. The degeneration of stichocytes and the absence of larvae in uterus were observed in the female worms recovered from mebendazole-treated mice. Levamisole had only a little effect on the migratory and encysted larvae. However, mebendazole was highly effective against the migratory and encysted larvae. The encysted larvae were more susceptible to mebendazole than the migratory larvae. The reduction rate of encysted larvae was almost 100%. The majority of the larvae recovered from mebendazole-treated mice were morphologically abnormal. Unhealthy condition such as the loss of body weight was observed in mice treated with mebenzdazole during the encysted phase. This side effect was assumed to be due to the allergic reaction provoked by antigens released from the dead larvae. It was confirmed that mebendazole was superior to levamisole in the treatments of enteral and parenteral trichinosis in mice.

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