+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Experimental coronary insufficiency effects of intra coronary administered catecholamines on coronary circulation cardiac function and myo cardial metabolism in dogs with graded coronary constriction



Experimental coronary insufficiency effects of intra coronary administered catecholamines on coronary circulation cardiac function and myo cardial metabolism in dogs with graded coronary constriction



Sapporo Medical Journal 50(6): 463-478



A physiological dose of catecholamines (CA) augments cardiac function, myocardial metabolism and coronary blood flow in the normal heart, while deleterious effects are seen in the heart with coronary constriction. These different effects, benefical or deleterious, may depend on the coronary blood flow (CBF) level. The interrelationship between the CA effect on myocardial metabolism or cardiac function and CBF level was established and the critical CBF level in which CA produces myocardial ischemia was determined. In 48 anesthetized open-chest dogs, the main left coronary artery was cannulated with Griggs type cannula. CBF was measured with electromagnetic flow meter and was reduced to the desired level (CBF 12-88 ml/min per 100 g) by means of graded constriction in the auto-perfused cannula circuit. The hemodynamic and metabolic measurements were performed before and after CBF reduction and following the intracoronary administration of 0.2 .mu.g/kg per min of adrenaline [epinephrine] (Ad) or 0.4 of noradrenaline [norepinephrine] (NA) for 5 min. Coronary constriction resulted in a slight decrease of mean coronary blood pressure, Max dp/dt of left ventricle, myocardial oxygen consumption (MVO2), coronary arteriovenous difference of lactate (.DELTA.L), lactate extraction ratio (.DELTA.L/La) and a slight elevation of left ventricular end-diastolic pressure (LVEDP) in proportion to the degree of CBF reduction. Myocardial K loss was below CBF 40 ml/min per 100 g. CA markedly increased Max dP/dt of left ventricle, MVO2, .DELTA.L, .DELTA.L/La, coronary arteriovenous difference of K and lowered LVEDP in dogs with CBF over 50 ml/min per 100 g. Both NA and Ad resulted in a significant production of lactate and K loss from myocardium, elevation of LVEDP and infarct-like ST elevation (6/12 dogs) or significant ST depression (other 6/12 dogs) in dogs with CBF under 30 ml/min per 100 g. The critical CBF level, in which CA produces myocardial ischemia, might exist between 30 and 50 ml/min per 100 g, and CA augments or improves cardiac function and myocardial metabolism in dog hearts with CBF over 50, and accelerates myocardial ischemia in those with CBF under 30 ml/min per 100 g.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 005422440

Download citation: RISBibTeXText


Related references

Experimental coronary insufficiency 18. effect of sympathetic nerve stimulation on coronary circulation cardiac function and myo cardial metabolism in dog hearts with coronary constriction. Japanese Circulation Journal 45(8): 867-868, 1981

Experimental coronary insufficiency 16. effect of sympathetic nerve stimulation right atrial pacing and intra coronary infusion of noradrenaline on cardiac function myo cardial metabolism and catecholamine release in the dog heart without coronary constriction. Japanese Circulation Journal 44(8): 607, 1980

Studies on experimental coronary insufficiency part 1 effects of a physiological dose of adrenaline and noradrenaline on myo cardial metabolism in dogs with graded coronary constriction. Kobayashi, Tachio, Toshio Ito And George Rona (Ed ) Recent Advances in Studies on Cardiac Structure And Metabolism, Vol 12 Cardiac Adaptation Proceedings Of The Eighth International Meeting Of The International Study Group For Research in Cardiac Metabolism (Now The International Society For Heart Research) Tokyo, Japan, May 26-29, 1976 Xv+751p Illus University Park Press: Baltimore, Md , Usa; London, England ISBN 0-8391-0672-6: 537-542, 1978

Effects of sympathetic nerve stimulation of coronary circulation cardiac function and myo cardial metabolism in the dogs with coronary constriction. Japanese Journal of Medicine 20(4): 321, 1981

Studies on experimental coronary insufficiency. I. Effects of a physiological dose of adrenaline and noradrenaline on myocardial metabolism in dogs with graded coronary constriction. Recent Advances in Studies on Cardiac Structure and Metabolism 12: 537-542, 1976

Effects of propranolol on regional myo cardial function and coronary blood flow pattern in conscious dogs with partial coronary constriction. Circulation Suppl. 54(2): II-44, 1976

Studies on experimental coronary insufficiency. II. Effects of beta-adrenergic blocking agent (propranolol) on metabolic response to adrenaline and noradrenaline in dogs with coronary constriction. Recent Advances in Studies on Cardiac Structure and Metabolism 12: 543-547, 1976

Studies on coronary circulation part 10 changes in coronary hemodynamics to constriction of left circumflex coronary artery in dogs. Japanese Circulation Journal 34(16): 939-940, 1970

Studies on experimental coronary insufficiency part 2 effects of beta adrenergic blocking agent propranolol on metabolic response to adrenaline and noradrenaline in dogs with coronary constriction. Kobayashi, Tachio, Toshio Ito And George Rona (Ed ) Recent Advances in Studies on Cardiac Structure And Metabolism, Vol 12 Cardiac Adaptation Proceedings Of The Eighth International Meeting Of The International Study Group For Research in Cardiac Metabolism (Now The International Society For Heart Research) Tokyo, Japan, May 26-29, 1976 Xv+751p Illus University Park Press: Baltimore, Md , Usa; London, England ISBN 0-8391-0672-6: 543-547, 1978

Regional myo cardial function during brief coronary occlusion and graded coronary stenoses in anesthetized dogs. Japanese Circulation Journal 46(8): 764, 1982

Significance of sympathetic nerve system on the precipitation of cardiac ischemia--effects of hyperlipidemia on the changes of coronary circulation, cardiac function and myocardial metabolism produced by sympathetic nerve stimulation in dog hearts with moderate coronary-constriction. Kokyu to Junkan. Respiration and Circulation 31(1): 25-28, 1983

Studies on coronary circulation part 16 effects of coronary vaso dilator drugs on inter coronary arterial anastomosis in coronary ligated dogs. Japanese Circulation Journal 37(8): 882, 1973

The role of catecholamines in cardiac function coronary circulation and myo cardial metabolism at rest and during exercise in cardiac patients. Japanese Circulation Journal 46(8): 780, 1982

Local myo cardial dimensions intra mural electro cardiogram and tissue flow during graded coronary constriction in dogs. Acta Physiologica Scandinavica Supplementum 440: 92, 1976

Experimental study of coronary circulation by coronary artery catheterization 5 Direct effects of various drugs on coronary circulation and electrocardiographic changes Direct effect of nicotine and ethyl alcohol on coronary circulation and the electro-cardiographic changes. Japanese Circulation Jour: 861-869, 1960