Experimental data on toxic action of hydrazine sulfate on the body and tumor

Filov, V.A.; Stukov, A.N.; Blank, M.A.; Neishtadt, E.L.

Farmakologiya i Toksikologiya 41(2): 203-205


Accession: 005422560

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Toxic action of hydrazine sulfate in rats and mice along with its influence on the mitotic activity of Walker carcinosarcoma cells was studied. Single injections of the agent in high doses resulted in destruction of the animals during the first 2 days with no delayed death observed. Multiple injections caused a considerable loss of body weight. When given in toxic doses the agent did not influence hemopoiesis, but did affect sensitivity, drastically increasing the toxic action of ethanol or barbiturates. Administration of hydrazine sulfate in therapeutic doses markedly decreased the mitotic activity and increased the appearance of atypical mitotic cells.