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Experimental hepatic amoebiasis entamoeba histolytica in the rabbit



Experimental hepatic amoebiasis entamoeba histolytica in the rabbit



Annals of Tropical Medicine & Parasitology 76(6): 615-622



Progressive acute and chronic hepatic amoebiasis was readily produced in rabbits by subcapsular intrahepatic inoculation of .apprx. 2 .times. 104 trophozoites of Entamoeba histolytica (along with their bacterial associates), at 0.05 ml/animal. Infant rabbits, 1-4 wk old, were more susceptible to infection than those aged 8-12 wk. Rabbits with hepatic lesions showed anorexia reduced activity and significant loss in weight and death. The necrotic lesion appeared .apprx. 2 days postinfection; it was yellowish-pink and became softer than the adjacent normal hepatic tissue from which it was sharply demarcated. Histological examination of the amoebic lesions showed extensive necrosis with polymorphonuclear and mononuclear celular infiltration, with the presence of amoebae. In advanced cases, a fibrotic reaction was observed at the edge of the lesions.

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Accession: 005423331

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