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Experimental infections of brush tailed possums trichosurus vulpecula common wombats vombatus ursinus and water rats hydromys chrysogaster with serovars leptospira interrogans balcanica and leptospira interrogans hardjo



Experimental infections of brush tailed possums trichosurus vulpecula common wombats vombatus ursinus and water rats hydromys chrysogaster with serovars leptospira interrogans balcanica and leptospira interrogans hardjo



Australian Journal of Experimental Biology & Medical Science 57(3): 231-240



Of 12 brush-tailed possums inoculated with L. interrogans serovar balcanica, 11 developed microagglutination (MA) antibody to hardjo antigen by 14 days post-inoculation (PI). Leptospiruria was observed in 2 possums at 117-145 days PI. Of 6 possums inoculated with serovar hardjo, 4 developed low short-lived titers by day 18 PI. Two of 3 wombats inoculated with balcanica had high MA titers (.gtoreq. 1:128) by day 16 PI and liptospiruria occurred by day 16. One wombat inoculated with hardjo developed a low MA titer. Low transitory MA titers to hardjo were found in 1 of 3 water rats after inoculation with balcanica and 1 of 2 given hardjo. Histopathological examination of kidneys revealed mild to moderately severe focal interstitial nephritis in 4 of 8 possums, in 2 wombats and in 2 water rats following experimental infection with balcanica. Similar lesions were observed in 2 of 4 possums, 1 wombat and 2 water rats following experimental infection with hardjo.

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Accession: 005423921

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Experimental infections of brush-tailed possums, common wombats and water rats with Leptospira interrogans serovars balcanica and hardjo. Australian Journal of Experimental Biology and Medical Science 57(3): 231-240, 1979

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