+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Experimental investigations on the diffusion of anti fibrinolytics in fibrin thrombi contribution to intra thecal anti fibrinolytic therapy in subarachnoid hemorrhages

Experimental investigations on the diffusion of anti fibrinolytics in fibrin thrombi contribution to intra thecal anti fibrinolytic therapy in subarachnoid hemorrhages

Folia Haematologica (Leipzig) 109(2): 313-318

The diffusion behavior and the diffusion coefficients of antifibrinolytics in fibrin thrombi were determined by in vitro incubation with 3H marked compounds of PAMBA [p-aminomethylbenzoic acid], AMCA [trans-4-aminomethylcyclohexanecarboxylic acid] and ECA [ethacrynic acid] as well as by chromogenic substrate determination for contrykal. The great diffusion ability of PAMBA supports the usefulness of intrathecal therapy for subarachnoid bleeding for blocking endogenous fibrinolysis, whereas the exogenous fibrinolysis of the fibrin thrombus closing aneurysm is inhibited by the intrathecal application. Citrated human plasma was used.

(PDF emailed within 1 workday: $29.90)

Accession: 005424182

Download citation: RISBibTeXText

Related references

Experimental studies on the diffusion of antifibrinolytic agents in fibrin thrombi. A contribution to intrathecal antifibrinolytic therapy in subarachnoid hemorrhages. Folia Haematologica 109(2): 313-318, 1982

Effect of anti fibrinolytic therapy on subarachnoid fibrosis in dogs after experimental subarachnoid hemorrhage. Acta Neurochirurgica 54(1-2): 17-24, 1980

Fibrinolytic changes in subarachnoid hemorrhage and anti-fibrinolytic therapy--application of an anti-plasmin agent (t-AMCHA). Nihon Rinsho. Japanese Journal of Clinical Medicine 36(3): 555-562, 1978

Monitoring of anti fibrinolytic therapy in subarachnoid hemorrhage from ruptured intra cranial saccular aneurysms. Acta Neurochirurgica 36(1/2): 154-155, 1977

Effects of anti thrombin anti plasmin and fibrinolytic agent uro kinase on the coagulation fibrinolytic system of experimental disseminated intra vascular coagulation syndrome. Acta Medica et Biologica 24(2): 55-68, 1976

Intra thecal hydro cortisone as treatment of subarachnoid hemorrhages. Neurobiologia (Recife) 30(3): 115-122, 1967

Fibrinolytic homeostasis in pregnancy. I. Quantitative relations between pro- and anti-fibrinolytic factors. Experimental and clinical contribution. Haematologica Latina 10(4): 409-422, 1967

Anti fibrinolytic therapy in ruptured intra cranial aneurysm through repeated monitoring of fibrinolytic activity of blood. Neurologia Medico Chirurgica 16(1): 91-96, 1976

The influence of drugs on disseminated intra vascular coagulation part 1 effects of anti fibrinolytics and fibrinolytics on thrombin induced disseminated intra vascular coagulation in rats. Thrombosis Research 9(2): 143-152, 1976

Anti fibrinolytic treatment in the pre operative management of subarachnoid hemorrhage caused by ruptured intra cranial aneurysm. Journal of Neurology Neurosurgery & Psychiatry 44(3): 220-226, 1981

Neopl brain tumor chemo therapy with intra thecal methotrexate anti neoplastic human. Cancer 23(5): 1038-1045, 1969

Intra thecal bromodeoxy uridine anti metabolite radiation therapy for malignant brain tumors. Brain Nerve (Tokyo) 24(5): 585-593, 1972

Prevention of experimental arterial spasm from subarachnoid hemorrhage by means of an anti fibrinolytic drug. Rivista di Neurologia 40(6): 424-436, 1970

Prospective trial of treatment for hemorrhages from meningeal aneurysms by deferred operation under cover of anti fibrinolytic therapy. Neurochirurgie 32(2): 122-128, 1986

Intra cranial hemorrhages under anti coagulant therapy. Acta Neurochirurgica 62(1-2): 124, 1982