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Experimental investigations on the diffusion of anti fibrinolytics in fibrin thrombi contribution to intra thecal anti fibrinolytic therapy in subarachnoid hemorrhages


Folia Haematologica (Leipzig) 109(2): 313-318
Experimental investigations on the diffusion of anti fibrinolytics in fibrin thrombi contribution to intra thecal anti fibrinolytic therapy in subarachnoid hemorrhages
The diffusion behavior and the diffusion coefficients of antifibrinolytics in fibrin thrombi were determined by in vitro incubation with 3H marked compounds of PAMBA [p-aminomethylbenzoic acid], AMCA [trans-4-aminomethylcyclohexanecarboxylic acid] and ECA [ethacrynic acid] as well as by chromogenic substrate determination for contrykal. The great diffusion ability of PAMBA supports the usefulness of intrathecal therapy for subarachnoid bleeding for blocking endogenous fibrinolysis, whereas the exogenous fibrinolysis of the fibrin thrombus closing aneurysm is inhibited by the intrathecal application. Citrated human plasma was used.

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Accession: 005424182



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