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Experimental iron deficiency in Syrian hamsters (Mesocricetus auratus)

Laboratory Animals 17(3): 210-212

Experimental iron deficiency in Syrian hamsters (Mesocricetus auratus)

An animal model was developed in which the effect of Fe deficiency on the oral mucosa could be studied. Fe deficiency was induced by feeding hamsters a low-Fe powdered diet together with withdrawal of 0.5 ml of blood weekly, for a period of 9 wk. At the end of this period the mean hematological values for control animals were, Hb 15.9 g/dl, plasma Fe 40.3 .mu.mol/l, TIBC [total Fe binding capacity] 90.5 .mu.mol/l and transferrin saturation 44.5%, compared with 7.4, 7.2, 111.4 and 6.5, respectively, for experimental animals. These results were reproducible in successive groups of animals and indicate that this is a useful model for the study of Fe deficiency anemia.

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Accession: 005424224

PMID: 6678343

DOI: 10.1258/002367783781070786

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