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Experimental iron deficiency in Syrian hamsters (Mesocricetus auratus)

Experimental iron deficiency in Syrian hamsters (Mesocricetus auratus)

Laboratory Animals 17(3): 210-212

An animal model was developed in which the effect of Fe deficiency on the oral mucosa could be studied. Fe deficiency was induced by feeding hamsters a low-Fe powdered diet together with withdrawal of 0.5 ml of blood weekly, for a period of 9 wk. At the end of this period the mean hematological values for control animals were, Hb 15.9 g/dl, plasma Fe 40.3 .mu.mol/l, TIBC [total Fe binding capacity] 90.5 .mu.mol/l and transferrin saturation 44.5%, compared with 7.4, 7.2, 111.4 and 6.5, respectively, for experimental animals. These results were reproducible in successive groups of animals and indicate that this is a useful model for the study of Fe deficiency anemia.

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Accession: 005424224

Download citation: RISBibTeXText

PMID: 6678343

DOI: 10.1258/002367783781070786

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