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Experimental lung lesion in mice by intra venous administration of soluble immune complexes



Experimental lung lesion in mice by intra venous administration of soluble immune complexes



Journal of the Osaka City Medical Center 29(2): 341-358



Soluble immune complexes consisting of rabbit antibody to bovine serum albumin (BSA) were made up at 5-fold and 20-fold antigen excess. Preformed 5-fold antigen excess BSA anti-BSA immune complexes were given twice i.v. to C57BL/6 mice at an interval of 6 h. An acute interstitial pneumonia, characterized by interstitial mononuclear cell infiltration, edema and congestion, was induced 24 h after the 1st injection. Similar histopathological changes were observed after 6 h when immune complexes were administered twice at a 3 h interval. Even at 30 min after the injection, similar but less prominent pulmonary changes were observed. Seventy-two hours after the 1st injection, the pulmonary inflammatory changes almost disappeared. Immunofluorescence showed that the antigen (BSA) and the antibody (rabbit .gamma.-globulin) located in alveolar capillary walls and infiltrating mononuclear cells. The mouse C3 [complement component 3] was observed in similar fashion although the immunofluorescence was very weak. When immune complexes of 20-fold antigen excess were given, the pulmonary inflammatory changes were very weak as compared with the changes elicited by the 5-fold antigen excess immune complexes. Inactivation of the mouse C system with the treatment of cobra venom factor showed no suppressive effect on the inflammatory changes caused by 5-fold antigen excess immune complexes. In vitro, the 5-fold antigen excess immune complexes had a much stronger C fixing activity than the 20-fold antigen excess immune complexes.

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