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Experimental maedi infection in sheep. 2. Antibody response






Acta Veterinaria Scandinavica 21(1): 124-133

Experimental maedi infection in sheep. 2. Antibody response

All 4 sheep inoculated via the respiratory tract with 7 .times. 106 TCID50 [median tissue culture infectious dose] of maedi M88 strain developed complement fixing (CF) antibodies [Ab] within 3 mo. after inoculation, and a gradual rise in CF titers was found during the first year. The Ab titers were maintained, though with some fluctuation through the following years; the titers vary from 64-256. Virus neutralizing activity against maedi M88 strain was detected in the sera of all intrapulmonarily inoculated sheep within 8 mo. after inoculation. Titers were maintained or slightly increased. The level of titers, ranging 8-256, was clearly different between individual sheep. Of the 4 sheep inoculated intracerebrally with 5 .times. 105 TCID50 of maedi M88 strain, 1 developed CF Ab 1 mo. after inoculation but no neutralizing Ab until death 11 mo. after inoculation. The rest of the intracerebrally inoculated sheep displayed no evidence of CF or neutralizing Ab within 18 mo. after inoculation in spite of numerous virus isolations from peripheral blood leukocytes. The absence of Ab might be attributed to phenomena such as differences in tropism, provirus state, immunological tolerance and size of inoculum. One sheep hyperimmunized with repeated s.c. and i.v. injections of maedi M88 strain developed high CF Ab titers but lower neutralizing Ab titers. The 2 uninoculated control sheep developed no CF or neutralizing Ab within 18 mo. after inoculation.

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Accession: 005424329

PMID: 7386321



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