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Experimental model for evaluating the possibilities of surgical treatment of pathological obesity


Annali Italiani di Chirurgia 58(2-4): 221-234
Experimental model for evaluating the possibilities of surgical treatment of pathological obesity
A study of the effects produced by a partial jejunoileal bypass, and by the subsequent surgical restoration to the original anatomical state, was carried out. The study included long-term monitoring of weight, laboratory results and histology. Four minipig and 4 Large White swine in the growth phase were used, and the data obtained following the bypass and the restoration were compared to corresponding parameters in swine of the same age not subjected to surgery. Arrest of weight increase after the bypass, and the rapid resumption of normal growth after the restoration, were observed and documented. The laboratory results furnished significant data only in the area of variations in the protein balance and in the transaminases. The restorative surgery had the effect in every case of restoring the original conditions. The conclusion was drawn that the effcts of the bypass are reversible in the time frame studied. It was also concluded that the proposed procedure should be modified as as to include more frequent monitoring and blood chemical measurement.

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Accession: 005424450



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