EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Experimental murine leprosy part 8 ultrastructural features of the inflammatory exudate and bacterial morphology in c 3h and c 57bl mice after foot pad inoculation with mycobacterium lepraemurium



Experimental murine leprosy part 8 ultrastructural features of the inflammatory exudate and bacterial morphology in c 3h and c 57bl mice after foot pad inoculation with mycobacterium lepraemurium



Acta Pathologica et Microbiologica Scandinavica Section A Pathology 83(6): 693-703



Mice of the inbred strains C57BL and C3H were inoculated in the foot-pads with M. lepraemurium (MLM) and the inflammatory reaction was studied using light microscopy and EM. In C57BL mice a granulomatous reaction developed 3-4 wk after inoculation. The inflammatory exudate at this stage showed numerous lymphocytes, monocytes and macrophages. The latter cell type often contained many lysosomes and appeared activated. The bacilli which were all within phagosomes showed extensive electron dense aggregates of the cytoplasm suggesting severe damage. Lymphocytes and macrophages in close contact with each other were often observed. In macrophages containing damaged bacilli, spherical lipid-like bodies surrounded by granular endoplasmic reticulum were observed. This cell product could be of some significance for the bactericidal function of the macrophage. The cellular infiltrate developing in C3H mice showed no lymphocytes and consisted exclusively of macrophages. These were all heavily loaded with bacilli. The vast majority of bacilli encountered in this strain was morphologically intact and presumably viable. Lipid-like bodies similar to those observed in infected C57BL macrophages were not encountered in C3H mice. Unless the infected macrophages become immunologically activated they are apparently unable to cause bacterial damage or to inhibit the growth of MLM.

(PDF 0-2 workdays service: $29.90)

Accession: 005424612

Download citation: RISBibTeXText



Related references

Experimental murine leprosy. 8. Ultrastructural features of the inflammatory exudate and bacterial morphology in C3H and C57BL mice after foot-pad inoculation with Mycobacterium lepraemurium. Acta Pathologica et Microbiologica Scandinavica. Section A, Pathology 83(6): 693-703, 1975

Experimental murine leprosy part 4 the gross appearance and microscopic features of the local infiltrate after sub cutaneous inoculation of c 3h and c 57bl mice with mycobacterium lepraemurium. Acta Pathologica et Microbiologica Scandinavica Section A Pathology 83(1): 59-68, 1975

Experimental murine leprosy part 9 antibodies against mycobacterium lepraemurium in c 3h and c 57bl mice with murine leprosy and in patients with lepromatous leprosy. Scandinavian Journal Of Immunology: 735-740, 1975

Experimental murine leprosy part 3 early local reaction to mycobacterium lepraemurium in c 3h and c 57bl mice. Acta Pathologica et Microbiologica Scandinavica Section A Pathology 83(1): 51-58, 1975

Experimental murine leprosy. 4. The gross appearance and microscopic features of the local infiltrate after subcutaneous inoculation of C3H and C57/BL mice with mycobacterium lepraemurium. Acta Pathologica et Microbiologica Scandinavica. Section A, Pathology 83(1): 59-68, 1975

Experimental murine leprosy part 6 cellular reactions in the draining lymph node after injection of mycobacterium lepraemurium into the foot pads of mice. Acta Pathologica et Microbiologica Scandinavica Section A Pathology 83(6): 683-692, 1975

Experimental murine leprosy: growth of Mycobacterium lepraemurium in C3H and C57/BL mice after footpad inoculation. Infection and Immunity 12(3): 480-489, 1975

Experimental murine leprosy. 6. Cellular reactions in the draining lymph node after injection of Mycobacterium lepraemurium into the foot-pads of mice. Acta Pathologica et Microbiologica Scandinavica. Section A, Pathology 83(6): 683-692, 1975

Experimental murine leprosy. IX. Antibodies against Mycobacterium lepraemurium in C3H and C57BL mice with murine leprosy and in patients with lepromatous leprosy. Scandinavian Journal of Immunology 4(7): 735-740, 1975

Experimental murine leprosy part 1 clinical and histological evidence for varying susceptibility of mice to infection with mycobacterium lepraemurium. Acta Pathologica et Microbiologica Scandinavica Section A Pathology 81(4): 401-410, 1973

Experimental murine leprosy part 2 further evidence for varying susceptibility of outbred mice and evaluation of the response of 5 inbred mouse strains to infection with mycobacterium lepraemurium. Acta Pathologica et Microbiologica Scandinavica Section A Pathology 82(4): 459-474, 1974

Experimental murine leprosy. 3. Early local reaction to mycobacterium lepraemurium in C3H and C57/BL mice. Acta Pathologica et Microbiologica Scandinavica. Section A, Pathology 83(1): 51-58, 1975

Experimental murine leprosy: induction of immunity and immune paralysis to Mycobacterium lepraemurium in C57BL mice. Infection and Immunity 12(4): 706-713, 1975

Experimental murine leprosy. I. Clinical histological evidence for varying susceptibility of mice to infection with Mycobacterium lepraemurium. Acta Pathologica et Microbiologica Scandinavica. Section A, Pathology 81(4): 401-410, 1973

Studies on murine leprosy bacillus part 4 attempt to cultivate in vitro the hawaiian strain of mycobacterium lepraemurium the further report on primary in vitro isolation sub cultivation reproduction test of the disease in mice of slow growing acid fast organisms supposedly murine leprosy bacillus. Kitasato Archives of Experimental Medicine 44(3-4): 167-183, 1971