+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Experimental neonatal syphilis 1. evidence of resistance to symptomatic infection in neonatal rabbits following intradermal inoculation with treponema pallidum nichols strain

Pediatric Research 18(10): 965-971

Experimental neonatal syphilis 1. evidence of resistance to symptomatic infection in neonatal rabbits following intradermal inoculation with treponema pallidum nichols strain

Resistance of 5- to 8-day-old neonatal rabbits to dermal lesion development after intradermal inoculation of T. pallidum was demonstrated. Clinical evidence of infection following inoculation of 1 .times. 106 T. pallidum at each of 2 sites was either minimal or absent. Atypical, nonprogressive, nonulcerative lesions occurred in 59% of the inoculated neonates and at 45% of inoculated sites. Differences in incubation periods, duration and maximum diameters of lesions among adult controls vs. neonatal rabbits were significant. The age of waning resistance was determined by inoculating groups of neonates ranging from 1 to 7 wk of age. Five-week-old (31-36 days) neonates demonstrated waning resistance by the appearance of typically ulcerative, progressive lesions, though their parameters (duration size) were not yet those of adult control lesions. The resistance demonstrated by neonates may be due in part to group housing (nesting) which could create unfavorable temperatures for T. pallidum survival; comparison of lesion development between nesting and individually housed neonates, 31 to 46 days of age, revealed a greater percentage of typical lesions developing among those individually housed (95 vs. 52%). However, these differences may reflect the variability of typical lesion development found among animals of this age when resistance begins to wane. In both groups, the duration of typical lesions was significantly shorter than for adult controls. A heat-stable serum factor(s) was demonstrated in 19 of 20 basal sera from neonates 4 to 6 days of age; this presented another possible mechanism of resistance. The neutralizing serum factor(s) was not demonstrable in the sera of does either before mating, during gestation or shortly after kindling. The relationship of temperature, serum factors and nutritional factors to neonatal resistance following intradermal inoculation with T. pallidum is discussed.

(PDF 0-2 workdays service: $29.90)

Accession: 005424698

PMID: 6387609

Related references

Experimental neonatal syphilis 2. immunological responses of neonatal rabbits to intradermal inoculation with treponema pallidum nichols strain. Pediatric Research 18(10): 972-979, 1984

Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by -irradiation. Journal of Immunology 110(5): 1206-1215, 1973

Syphilis Maintenance of the Nichols strain of Treponema pallidum in rabbits. 1966

On Antibody Formation In Treated Syphilis Patients After Intradermal Inoculation Of Killed Treponema (Nichols Strain). Rivista Dell'istituto Sieroterapico Italiano 39: 263-270, 1964

TprK sequence diversity accumulates during infection of rabbits with Treponema pallidum subsp. pallidum Nichols strain. Infection and Immunity 74(3): 1896-1906, 2006

The course of syphilis infection in C4D guinea pigs infected with GP-adapted strain of Treponema pallidum, Nichols. Abstracts of the General Meeting of the American Society for Microbiology 96(0): 250, 1996

Some experimental research on the behavior of 3 strains of treponema pallidum strain nichols strain nichols cortisone hormone treated and strain gand. Annales de Dermatologie et de Syphiligraphie 95(1): 59-68, 1968

Various experimental studies on the behavior of 3 strains of Treponema pallidum (Nichols strain, cortisone treated Nichols strain and Gand strain). Annales de Dermatologie et de Syphiligraphie 95(1): 59-68, 1968

The antigenic interrelationship between the endoflagella of treponema phagedenis biotype reiter and treponema pallidum nichols strain i. treponemicidal activity of cross reactive endoflagellar antibodies against treponema pallidum. Journal of Immunology 137(9): 2973-2979, 1986

Maintenance of the nichols strain of treponema pallidum in rabbits. Pasteur Institute of Southern India Coonoor Annual Report of the Director & Scientific Report (1968): 148, 1969