EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Experimental partial sympathicotonia, and effects of some drugs on it in restraint and water immersion stressed animals


Journal of Pharmacobio-Dynamics 3(12): 692-701
Experimental partial sympathicotonia, and effects of some drugs on it in restraint and water immersion stressed animals
The contractile response to acetylcholine (ACh) of the isolated duodenum from the restraint and water immersion stressed (RWIS) mouse was found to be enhanced by the stress for 1 hr and reach a maximum in 3 hr stress followed by a decrease. It was clarified that this rise in the response is not due to the change in the affinity to ACh but due to the increase of the intrinsic activity. The contractile response to KC1 was augmented only when concentration of KC1 was high, While the response to BaCl2 was little enhanced in the stressed animal. The relaxing response to noradrenaline (NA) of the isolated duodenum from rat, on the other hand, was reduced by the stress. Such reduced response to NA was observed to be more marked than the enhanced response to ACh in the vas deferens isolated from the stressed animal. The pretreatment to the RWIS mouse with either antiadrenergic or cholinergic drugs resulted in the clear-cut blockade of the enhancement of response to ACh of the isolated duodenum from this animal. These results contrasted to the effects on the reduced response to ACh of the isolated duodenum from the SART stressed (repeated cold stressed) mouse. The pre-administration of psychotropic drugs showed marked suppression on the enhancement of response of the duodenum of the RWIS animal, though there was a quantitative difference between the RWIS and SART animals. The pretreatment with a neurosedative, Neurotropin (NSP) was also found to show similarly marked suppressive action. From these results, it was considered that the duodenum and the vas deferens of the RWIS animal are in the state of the sympathicotonia, namely partial sympathicotonia.


Accession: 005424910

PMID: 7277184

DOI: 10.1248/bpb1978.3.692



Related references

Experimental pharmacological study on partial sympathicotonia in restraint and water immersion stressed animals. Journal of Pharmacobio-Dynamics 4(4): 251-261, 1981

Abnormal ECG and adrenaline-induced arrhythmias in restraint and water immersion stressed mice and effects of oxprenolol. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 83(5): 373-382, 1984

An abnormal electro cardiogram and the adrenaline induced arrhythmias in restraint and water immersion stressed mice and the effects of oxprenolol on them. Folia Pharmacologica Japonica 83(5): 373-382, 1984

Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats. Scientifica 2016: 7825396-7825396, 2016

Body temperature dependent decrease of gastric blood flow in restraint and water-immersion stressed rats. Journal of Pharmacobio-Dynamics 9(8): 678-682, 1986

Colonic submucosal 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in water-immersion restraint stressed rats. European Journal of Pharmacology 656(1-3): 94-100, 2011

Body temperature dependency of gastric regional blood flow, acid secretion and ulcer formation in restraint and water-immersion stressed rats. Japanese Journal of Pharmacology 40(4): 501-504, 1986

A discussion of the problems of restraint in experimental investigations of acceleration injury. A lucite water immersion restraint for a vibration injury study with cats. Journal of Biomechanics 2(2): 157-162, 1969

Experimental studies on neurogenic stress ulceration device of a laparotomy restraint stress model in rats with subarachnoid hemorrhage and comparison with a restraint water immersion stress model. Acta Scholae Medicinalis Universitatis in Gifu 36(1): 28-67, 1988

An experimental study on the effect of intravenous hyperalimentation on a rat with ulcer induced stress by restraint of water immersion. Tokyo Jikeikai Medical Journal 103(1): 347-366, 1988