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Experimental pemphigus in balb c mice first observations

Experimental pemphigus in balb c mice first observations

Revista Argentina de Dermatologia 66(3): 165-172

Human serum from pemphigus vulgaris and pemphigus vegetans patients were injected intraperitoneally in Balb-c neonates with daily doses of 0.125 ml, 0.25 ml or 0.35 ml. (between 0.60 g to 4.60 mg. of IgG per gram of body weight). I.I.F. showed titers of 1/10 in serum of pemphigus. Five of the seven animals showed the histopathology of pemphigus (4 suprabasal and 1 subcorneal). Three developed cutaneous blisters, erosions and crusts. We found three histopathological patterns: (1) pemphigus vulgaris, (2) pemphigus vulgaris with epidermal regneration signs and (3) pemphigus foliaceus. Some degree of correlation between the amount of serum injected and the appearance of the disease in mice is seen. Induction of pemphigus in neonatal Balb-c mice by passive transfer of IgG from patients with the disease was obtained.

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