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Experimental pharmacological study of 3 species from genus salvia


Acta Physiologica et Pharmacologica Bulgarica 10(2): 13-20
Experimental pharmacological study of 3 species from genus salvia
Extracts (15) isolated from 3 spp. of genus Salvia were studied: 2 from S. officinalis, 7 from S. triloba and 6 from S. verbenaca. Their effects on the blood pressure of cats and spontaneously hypertensive rats were examined. The smooth-muscle effects of the extracts were studied on isolated segments of guinea pig ileum. The effects of some of the extracts on hexobarbital anesthesia were investigated. Applied i.v. and duodenally, aqueous-alcohol extract of S. officinalis causes moderate, but prolonged, lowering of the blood pressure in cats. Decoction of S. triloba also possesses a similar effect (in experiments on spontaneously hypertensive rats). Most of the extracts isolated from S. officinalis and S. triloba inhibit to various degrees smooth-muscle contractions induced by acetylcholine, histamine, serotonin and BaCl2; extracts of S. verbenaca usually potentiated them. Substances isolated from S. triloba prolong hexobarbital sleep. Future studies of substances isolated from S. officinalis and S. triloba are promising with a view to their spasmolytic and hypotensive actions. There exist marked interspecies differences in the pharmacological effects of biologically active substances isolated from genus Salvia.


Accession: 005424948



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Experimental pharmacological study of three species from genus Salvia. Acta Physiologica et Pharmacologica Bulgarica 10(2): 13-20, 1984

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