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Experimental poisoning by the pods and pericarp of dimorphandra mollis leguminosae caesalpinioideae in rabbits

Experimental poisoning by the pods and pericarp of dimorphandra mollis leguminosae caesalpinioideae in rabbits

Pesquisa Veterinaria Brasileira 5(3): 93-96

During 14 days, four young rabbits were fed exclusively with dried pods, and four others with dried pericarps of Dimorphandra mollis. Two additional rabbits were fed concentrated ration and served as controls. The only clinical observation was a progressive weight loss, probably due, in part, to the low food consumption. The two animals that ingested the largest quantities of dried pods (25.4 g/kg/day) and pericarp (22.9 g/kg/day) were sacrificed. Necropsy revealed pale kidneys, which in one, the centers of the liver lobules were darker. The most important histological findings were seen in the kidneys, which demonstrated a severe hydropic vacuolar degeneration of the proximal convoluted tubules and mild congestion of the glomeruli. In the liver of the animal that showed macroscopic liver alterations, degenerative necrotic lesions were seen in the periportal hepatocytes. The animals that were not killed were given ration and recovered. The histological alterations confirm the nephrotoxic character of D. mollis as already described for cattle. However, rabbits were shown to be more resistant to the toxic action of the plant, as they did not die when given doses much larger than those needed to cause death in cattle.

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Accession: 005425007

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