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Experimental study of healing effect of topical application of thyrocalcitonin on jaw defects in dogs



Experimental study of healing effect of topical application of thyrocalcitonin on jaw defects in dogs



Pakistan Veterinary Journal 5(1): 5-11



Six groups (3 experimental and 3 control), each of 12 dogs, were used. A circumscribed mandibular defect was filled with fresh rib autogenous graft (group I and IV), preserved homogenous graft (group II and V) pre-cut piece of collagen (group III and VI). Calcitonin (CT) was topically applied to that defect in the experimental groups I, II and III. Thyrocalcitonin had no side effects when used at the recommended dose level. The optimal healing effect of the topically applied hormone appeared after 2 wk, then diminished gradually. In the meantime it promoted osteoblastic bone formation and inhibited the rate of osteoclastic bone resorption. The hormone may be recommended for use in large surgical bony defects. CT was not preferable to be used with autogenous bone grafts but it was advantageously used with homogenous ones.

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Accession: 005426754

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