EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Expression of 2 variant surface glycoproteins on individual african trypanosomes during antigen switching



Expression of 2 variant surface glycoproteins on individual african trypanosomes during antigen switching



Science (Washington D C) 229(4709): 190-193



Individual Trypanosoma brucei rhodesiense organisms were observed in the process of switching variant surface glycoproteins (VSG). During this switch, trypanosomes simultaneously expressed both pre- and postswitch VSG uniformly over their surface as detected with monoclonal antibodies. Analysis of this switching event showed that trypanosomes expressing any one of 3 distinct preswitch VSG could switch to expression of from 1-3 different postswitch VSG. Up to 2.7% of the trypanosome population was in the process of switching at one time.

(PDF emailed within 1 workday: $29.90)

Accession: 005429876

Download citation: RISBibTeXText



Related references

Expression of two variant surface glycoproteins on individual African trypanosomes during antigen switching. Science 229(4709): 190-193, 1985

The biochemistry of variant surface glycoproteins of the African trypanosomes. Biochemical Society Symposium 49: 169-181, 1984

Control of variant surface antigen switching in trypanosomes. Cell Cambridge 51: 159-161, 1987

Amino terminal sequence homology among variant surface glycoproteins of African trypanosomes. Molecular and Biochemical Parasitology 12(3): 287-298, 1984

Rapid preparative scale purification of myristylated variant surface glycoproteins from African trypanosomes. Molecular and Biochemical Parasitology 17(1): 19-34, 1985

Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site. Dna and Cell Biology 29(5): 215-227, 2010

The membrane-anchoring systems of vertebrate acetylcholinesterase and variant surface glycoproteins of African trypanosomes share a common antigenic determinant. FEBS Letters 199(2): 182-186, 1986

Expression of variant-specific antigen genes in African trypanosomes. Biology of the Cell 64(2): 121-130, 1988

Co-duplication of a variant surface glycoprotein gene and its promoter to an expression site in African trypanosomes. Journal of Biological Chemistry 272(39): 24637-24645, 1997

Selective expression of surface antigen genes in African trypanosomes. Parasitology Today 2(1): 15-19, 1986

Leaky transcription of variant surface glycoprotein gene expression sites in bloodstream african trypanosomes. Journal of Biological Chemistry 274(24): 16884-16893, 1999

Analysis of a donor gene region for a variant surface glycoprotein and its expression site in African trypanosomes. Nucleic Acids Research 29(10): 2012-2019, 2001

Secondary structure potential of the variant specific glycoproteins of african trypanosomes. Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie 365(9): 1024, 1984

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes. Bmc Genomics 17(1): 806-806, 2016

Biochemistry of the variant surface glycoproteins of salivarian trypanosomes. Advances in Parasitology 21: 69-153, 1982