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Expression of myosin isozymes during the developmental stage and their redistribution induced by pressure overload


, : Expression of myosin isozymes during the developmental stage and their redistribution induced by pressure overload. Japanese Circulation Journal 50(10): 1044-1052

Cardiac muscles contain at least two isozymes.sbd.referred to as .alpha.(HC.alpha.) and .beta.(HC.beta.).sbd.of the myosin heavy chain. The proportional ratio of these isozymes varies depending upon the developmental stage and the physiological and/or the hormone milieu of the cell. Using monoclonal antibodies (MoAb) specific for human cardiac HC.alpha. and HC.beta., we have examined the expression of these isozymes in fetal through adult cardiac tissues and investigated whether isozymic redistribution occurs in pressure overloaded human ventricles. We found that 1) although HC.alpha. was expressed in the atrium from the early embryonic stage, in embryonic ventricular myofibers, only HC.beta. was expressed without expression of HC.alpha., but some myofibers replace HC.beta. by HC.alpha. after birth, and 2) these HC.alpha. containing ventricular myofibers were found to be decreased by pressure overload, which suggested that isozymic redistribution from HC.alpha. to HC.beta. also occurred in the ventricles as well as the atrium. In addition, we also found two subtypes of HC.beta. (.beta.1, .beta.2) in the human heart. In the ventricle, both .beta.1 and .beta.2 was present in all myofibers; in contrast, some myofibers contained .beta. or .beta.2 or both with or without expression of HC.alpha. in the atrium. .beta.1 and .beta.2 were distinctive in their expression during the development stage, since .beta.1 was present in the embryonic heart from the early developmental stage, whereas .beta.2 was not present in the early embryonic heart, but began to be expressed in the late embryonic stage. Therefore, there are at least three types of myosin isozymes, HB.alpha., .beta.1 and .beta.2, whose expression is regulated by pressure overload and developmental stage.

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Accession: 005431420

PMID: 3806928

DOI: 10.1253/jcj.50.1044

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