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Expression of neuro ectodermal antigens common to melanomas gliomas and neuro blastomas 1. identification by mono clonal anti melanoma and anti glioma antibodies

Expression of neuro ectodermal antigens common to melanomas gliomas and neuro blastomas 1. identification by mono clonal anti melanoma and anti glioma antibodies

Acta Neuropathologica 57(2-3): 158-164

The reactivity spectrum of 5 monoclonal anti-melanoma antibodies cross-reacting with [human] gliomas and neuroblastomas and 1 monoclonal anti-glioma antibody cross-reacting with melanomas and neuroblastomas was investigated. Comparison of the binding activity of these monoclonal antibodies for 11 melanoma, 7 glioma, and 3 neuroblastoma cell lines showed that each of these clones had a different pattern of cross-reactivity. The results indicated that the antigenic determinants detected by these antibodies were not associated with the same antigen and suggested the existence of at least 6 different antigens common to melanomas, gliomas and neuroblastomas. Since all these tumors are known to derive from cells originating embryologically from the neural crest, it can be assumed that the antigens recognized by these monoclonal antibodies are neuroectodermal differentiation antigens. However, absorption with fetal brain homogenates abolished only the binding of monoclonal anti-glioma antibody, but did not modify the binding of monoclonal anti-melanoma antibodies.

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Accession: 005431438

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PMID: 6181646

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