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Expression of the h y antigen on thymus cells and skin differential genetic control linked to k end of h 2

, : Expression of the h y antigen on thymus cells and skin differential genetic control linked to k end of h 2. Immunogenetics 3(6): 583-594

The strength of the H-Y antigen on thymus cells and on skin was compared in different H-2-congenic mouse strains using a host-vs.-graft reaction popliteal lymph node assay, and skin grafts from males of parental strains grafted to F1 hybrid females. The results revealed considerable differences in the strength of the H-Y antigen among different congenic strains; these differences demonstrate the effect of the H-2-linked gene on the expression of the H-Y antigen. The linkage with H-2 was also confirmed in tests with segregating F2 generations. In the strains bearing recombinant H-2 haplotypes, the strength of the H-Y antigen is similar to that of parental strain from which the recombinant received its K end, and the responsible gene (or genes) map to the left of I-C. The effect of the H-2-linked gene(s) on thymus cells and skin is different. The gene linked to the K end of H-2b determines a strong H-Y antigen on thymus cells, but a relatively weak H-Y antigen on skin. The gene linked to the K end of H-2k determines a weak H-Y antigen on thymus cells, but a strong H-Y antigen on skin. The gene linked to the K end of H-2d determines a weak H-Y antigen on both thymus cells and skin. These observations raise the possibility that the structural gene for the H-Y antigen is linked to H-2. Alternative (but not exclusive) explanations invoke regulatory effects of H-2 on the expression of the H-Y antigen, possibly by means of the control of the cellular andogen receptors.

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