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Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma


, : Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma. Somatic Cell & Molecular Genetics 11(3): 297-302

Epidermal growth factor (EGF) receptor is expressed selectively by human melanoma cells which show the presence of an extra copy of chromosome 7. None of the cells of benign pigmented lesions (nevi) or radial growth phase (nonmetastic) primary melanoma expressed EGF receptor and none of these cells showed an extra copy of chromosome 7. A single extra dose of a gene (for EGF receptor) may provide a selective advantage to cells in the late stages of tumorigenesis.

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Accession: 005432202

PMID: 2988138

DOI: 10.1007/bf01534687

Download PDF Full Text: Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma


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