EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma


Somatic Cell & Molecular Genetics 11(3): 297-302
Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma
Epidermal growth factor (EGF) receptor is expressed selectively by human melanoma cells which show the presence of an extra copy of chromosome 7. None of the cells of benign pigmented lesions (nevi) or radial growth phase (nonmetastic) primary melanoma expressed EGF receptor and none of these cells showed an extra copy of chromosome 7. A single extra dose of a gene (for EGF receptor) may provide a selective advantage to cells in the late stages of tumorigenesis.

Accession: 005432202

PMID: 2988138

DOI: 10.1007/bf01534687

Download PDF Full Text: Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma



Related references

Chromosome 7 aneusomy. A marker for metastatic melanoma? Expression of the epidermal growth factor receptor gene and chromosome 7 aneusomy in nevi, primary malignant melanomas and metastases. Neoplasia 3(3): 245-254, 2001

Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America 83(14): 5141-5144, 1986

Enhanced expression of the receptor for epidermal growth factor correlates with alterations of the short arm of chromosome 7 in human pancreatic cancer. Digestive Diseases & Sciences: 978, 1985

Increased expression of epidermal growth factor receptor in rat pleural mesothelial cells correlates with carcinogenicity of mineral fibres. Carcinogenesis 21(12): 2275-2280, 2001

Increased epidermal growth factor receptor (EGFR) expression in malignant mammary phyllodes tumors. Breast Cancer Research and Treatment 114(3): 441-448, 2008

Epidermal growth factor receptor expression in human malignant glioma: in vitro and in vivo effects of application of monoclonal antibodies to the epidermal growth factor receptor. Recent Results in Cancer Research. Fortschritte der Krebsforschung. Progres Dans les Recherches sur le Cancer 135: 171-184, 1994

Growth factor modulation of melanoma growth stimulatory activity mRNA expression in human malignant melanoma cells correlates with cell growth. Journal of Cellular Biochemistry 39(4): 421-428, 1989

Growth factor modulation of melanoma growth stimulatory activity messenger rna expression in human malignant melanoma cells correlates with cell growth. Journal of Cellular Biochemistry 39(4): 421-428, 1989

Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by Gefitinib and Cetuximab triggered antibody-dependent cellular cytotoxicity. European Journal of Cancer 49(15): 3353-3365, 2014

Intestinal adaptation is enhanced by epidermal growth factor independent of increased ileal epidermal growth factor receptor expression. Journal of Pediatric Surgery 33(7): 980-4; Discussion 984-5, 1998