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Expression of the t cell surface molecule cd2 and an epitope loss cd2 mutant to define the role of lymphocyte function associated antigen 3 lfa 3 in t cell activation

, : Expression of the t cell surface molecule cd2 and an epitope loss cd2 mutant to define the role of lymphocyte function associated antigen 3 lfa 3 in t cell activation. Proceedings of the National Academy of Sciences of the United States of America 85(4): 1194-1198

To define the role of the CD2-lymphocyte function-associated antigen 3 (LFA-3) interaction in T-cell activation, we have expressed a cDNA encoding the human CD2 molecule in amurine antigen-specific T-cell hybridoma. Expression of the CD2 molecule greatley enhances t-cell responsiveness to antigen; this enhancement is inhibited by anti-CD2 and anti-LFA-3 monoclonal antibodies (mAbs).

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