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Expression of thymus derived cell suppressor activity in the immune response of new born mice to a thymus derived independent synthetic poly peptide


Immunology 35(5): 757-762
Expression of thymus derived cell suppressor activity in the immune response of new born mice to a thymus derived independent synthetic poly peptide
One and 2 day old mice responded to the T[thymus derived cell]-independent synthetic polypeptide poly (DTyr,DGlu)-poly(DPro)-poly(DLys) with high antibody production, whereas a dramatic decrease was observed in the immune response of 3 day old injected animals. The presence and expression of suppressor T cells in the 3 day old newborn mice spleens was demonstrated by transferring spleens of 3 day old mice into thymectomized, irradiated recipients together with bone-marrow cells, or into 1-2 day old newborn recipients. In both cases a significantly lower antibody response was observed in recipients of the 3 day old newborn spleen cells as compared to recipients of the same number of adult spleen cells. No decrease in the antibody levels was detected following inoculation of 3 day old spleen cells after anti-.theta.-treatment, while enriched T cell populations obtained from nylon wool columns had the same suppressive effect as the whole spleen cell preparations. The cell expressing the suppressor activity in the newborn spleen is a T cell.

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Accession: 005432309



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