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Expression of transfected human copper zinc superoxide dismutase gene in mouse l cells and ns20y neuroblastoma cells induces enhancement of glutathione peroxidase activity

, : Expression of transfected human copper zinc superoxide dismutase gene in mouse l cells and ns20y neuroblastoma cells induces enhancement of glutathione peroxidase activity. Biochimica et Biophysica Acta 949(1): 58-64

The human CuZn superoxide dimutase (superoxide dismutase 1) a key enzyme in the metabolism of oxygen free-radicals, is encoded by a gene located on chromosome 21 in the region 21 q 22.1 known to be involved in Down's syndrome. A gene dosage effect for this enzyme has been reported in trisomy 21. To assess the biological consequences of superoxide dimutase 1 overproduction within cells, the human superoxide dismutase 1 gene and a human superoxide dismutase 1 cDNA were introduced into mouse L cells and NS20Y neuroblastoma cells. Both cell types expressed elevated levels (up to 3-fold) of enzymatically active human superoxide dismutase 1. These human superoxide dismutase 1 overproducers, especially neuronal cell lines, showed an increased activity in the selenodependent glutathione peroxidase. These data are consistent with the possibility that gene dosage of superoxide dismutase 1 contributes to oxygen metabolism modifications previously described in Down's syndrome.

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