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Expression of transformation in cell hybrids part 2 nonsuppression of the transformed phenotype in hybrids between a chemically transformed and nontransformed derivatives of balb 3t3

, : Expression of transformation in cell hybrids part 2 nonsuppression of the transformed phenotype in hybrids between a chemically transformed and nontransformed derivatives of balb 3t3. Journal of Cellular Physiology 97(2): 147-152

Hybrid clones derived from a nitrosocarbaryl-transformed Balb/3T3 mouse fibroblast cell line, clone H, and a nontransformed cell line THO2 resemble the transformed parent in clone morphology, higher saturation density, colony formation in medium with reduced serum concentration, growth in agarose and ability to form clones on Balb/3T3 monolayers. Results are discussed in the framework of genetic models which permit or require dominant mutations for the expression of transformed phenotype.

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