EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Expression of tumor associated antigens by a producer and a nonproducer leukemia induced by rauscher virus






Cellular Immunology 42(2): 373-383

Expression of tumor associated antigens by a producer and a nonproducer leukemia induced by rauscher virus

Two Rauscher virus (R-MuLV)-induced [mouse] leukemias, RBL-5, a virus-producer, and RBL-3, a nonproducer, were compared for their expression of cell surface antigens [Ag] (RCSA), by cytotoxicity, membrane immunofluorescence, R-MuLV neutralization, and complement-fixation assays using syngeneic anti-crude membrane sera and anti-gp69/71, anti-p30 and anti-R-MuLV sera. There was a higher concentration of gp69/71 and p30 on the RBL-3 membrane than on RBL-5. This presumably is due to a cellular block at a step before assembly of virus, resulting in accumulation of these viral structural proteins (VSP). The common Ag on RBL-3 and RBL-5 is called RCSAa and may be composed of gp69/71 (RCSAa1) and an unidentified Ag (RCSAa2) which reacts more effectively with syngeneic antisera than against anti-VSP sera. An Ag abundant on the membrane of RBL-3 but not on RBL-5 is designated RCSAb, which is probably identical with p30. An unidentified Ag designated RCSAc is present on RBL-5, but not on RBL-3. Ascites cells of RBL-3 and RBL-5 exhibited less RCSA than did the cultured lines.


Accession: 005432358

PMID: 427880



Related references

Mouse mammary tumor virus and murine leukemia virus cell surface antigens on virus producer and nonproducer mammary epithelial tumor cells. Virology 88(2): 379-383, 1978

Immune reactivity of RBL-3, a nonproducer leukemia induced by Rauscher murine leukemia virus in C57BL/6 mice. Journal of the National Cancer Institute 61(1): 107-112, 1978

The rauscher murine leukemia virus induced leukemia rbl 5 bears two tumor associated transplantation antigens expressed on distinct molecules. International Journal of Cancer 36(6): 713-720, 1985

Rauscher leukemia virus-induced tumor antigens: complete separation from gp70, p30 and H-2. International Journal of Cancer 24(5): 608-615, 1979

Rauscher leukemia virus induced tumor antigens complete separation from glyco protein 70 protein 30 and h 2. International Journal of Cancer 24(5): 608-615, 1979

Release of mouse mammary tumor virus envelope glycoprotein from virus producer and nonproducer cells. Abstracts of the Annual Meeting of the American Society for Microbiology 86: 324, 1986

The Rauscher-MuLV-induced leukemia, RBL-5, bears two tumor-associated transplantation antigens expressed on distinct molecules. International Journal of Cancer 36(6): 713-719, 1985

Feline leukemia virus-and feline sarcoma virus-related polypeptides released by virus producer and nonproducer cells. Cancer Investigation 3(6): 523-534, 1985

Separation of the tumor rejection antigen from the major viral structural proteins associated with the membrane of an rauscher murine leukemia virus induced leukemia. International Journal of Cancer 21(2): 246-252, 1978

Cell-surface antigens induced by Friend and Rauscher virus complexes and their associated lymphatic leukemia viruses in the rat. Cancer Research 35(7): 1718-1722, 1975