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Expression of type c virus protein p 30 in mouse cells infected with herpes simplex virus


, : Expression of type c virus protein p 30 in mouse cells infected with herpes simplex virus. Virology 83(2): 438-443

Expression of type C virus protein p30 in BALB/c and NIH Swiss mouse cells infected with live (productive infection) or UV-irradiated herpes simplex virus (UV-HSV) types 1 and 2 was studied by immunofluorescent (FA) or radioimmunoassay (RIA) procedures. No evidence for enhanced expression of p30 was obtained with either of these procedures although activation of type C virus in UV-HSV-infected BALB/c cells was readily demonstrated at low frequencies (.apprx. 10-4) by infectious center assay. While FA staining with rabbit anti-murine leukemia virus (MuLV) p30 serum was observed in mouse cells productively infected with HSV or infected with UV-HSV, this was shown to be nonspecific. Activation of type C virus in UV-HSV-infected BALB/c cells apparently does not occur in significantly more cells than detected by infectious center assay.

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