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Expression of type specific virion structural antigens in l cells transformed by herpes simplex virus type 1 and type 2


Virology 76(1): 433-436
Expression of type specific virion structural antigens in l cells transformed by herpes simplex virus type 1 and type 2
Antisera prepared against thymidine kinaseless (tk-) L cells [mouse fibroblasts] (Ltk-) transformed to the tk+ phenotype by herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) preferentially agglutinated purified homologous virions. Transformed cell antisera were much less effective in agglutinating nucleocapsids than they were in agglutinating envelope material from the homologous virus. Antiserum prepared against untransformed Ltk- cells agglutinated about twice as much virus as did preimmune serum but only 13-19% as much as was agglutinated by transformed cell antisera. HSV-1- and HSV-2-transformed L cells apparently express an HSV type-specific structural antigen(s) and this antigen may be present in the envelope of the virion. Since the transformed cell antisera also agglutinated the heterologous virus but to a lesser extent than the homologous virus, these antisera were also capable of detecting type-common antigenic determinants.


Accession: 005432382



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