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Expression of viral proteins in mammalian cells transformed by avian sarcoma viruses


, : Expression of viral proteins in mammalian cells transformed by avian sarcoma viruses. International Journal of Cancer 18(6): 787-797

The expression of viral proteins in 9 lines of hamster and RB12 [RS2 fibroblast sublines, and RBHtc sarcoma] and rat [XCtc and 17RBI77 sarcoma, and TWERC embryo] cells transformed by avian sarcoma viruses (ASV) was studied by indirect immunofluorescence with monospecific antisera to purified gp85 and p27 of AMV[avian myeloblastosis virus]-B and a polyvalent antiserum to all the p proteins of this same virus. The lines of ASV-transformed cells were either low virus producers (VP) or inducible or non-inducible nonproducers (NP). Cytoplasmic expression of p proteins were observed in all the cell lines except the least inducible NP cell line and cytoplasmic expression of gp85 in all the cell lines. The degree of expression varied widely with the lines and was not related to the class of permissiveness or inducibility. In the inducible NP class, the expression of p proteins and gp85 was higher in the most inducible cell lines. The expression of the p proteins apparently must be uncoordinate in at least some cell lines and must also be uncoordinate with the expression of gp85. In the VP cell lines and the most inducible NP lines, gp85 and of the p proteins which were expressed appeared to be coordinate and to parallel the degree of cytoplasmic expression. In contrast, no, or a negligible expression of viral proteins was observed on the membrane of the least inducible and the non-inducible cell lines. There may exist translational and/or post-translational controls of the expression of viral proteins in the ASV-transformed mammalian cells. The permissiveness and the inducibility of the cells may depend on the insertion of viral proteins in the cell membrane. The failure of p27 to insert in the cell membrane could account for the low permissiveness or the non-permissiveness of the cells.

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Accession: 005432422

PMID: 186419

DOI: 10.1002/ijc.2910180610

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