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Expression of virulence factors of bacteria when grown in the presence of subminimum inhibitory concentrations of various antibiotics


, : Expression of virulence factors of bacteria when grown in the presence of subminimum inhibitory concentrations of various antibiotics. Drugs under Experimental & Clinical Research 8(3): 245-250

The ability of a variety of bacteria to elaborate toxins and enzymes was influenced by sub-MIC [minimum inhibitory concentrations] of various antibiotics. Clindamycin prevented the formation of coagulase, .alpha.-hemolysin, DNase and other exotoxins by Staphylococcus aureus in vitro. Such effects were observed in experimental infections in mice with corresponding changes in the host response to the infecting organism. The hemolysin of Escherichia coli was inhibited by streptomycin; the proteases of Pseudomonas aeruginosa were inhibited by tetracycline. The enterotoxin of E. coli and Vibrio cholerae was stimulated by clindamycin; the .beta.-hemolysins of S. aureus and pneumococci were stimulated with sub-MIC of penicillin.

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