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Expression of vitiligo antigen on a revertant line of hamster melanoma cells


, : Expression of vitiligo antigen on a revertant line of hamster melanoma cells. Journal of Investigative Dermatology 83(5): 317-319

Over 80% of the patients with common vitiligo have circulating antibodies to cell-surface antigens on normal human melanocytes. The slow growth rate of these cells limits the assays that can be performed for antibody detection. The antigens defined by vitiligo sera on melanocytes are also expressed on FF cells, a revertant line of hamster melanoma cells. These antigens can be detected both by indirect immunofluorescence and specific immunoprecipitation assays. The presence of vitiligo antigens on hamster FF cells will aid further study of the abnormal immune response in vitiligo.

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Accession: 005432431

PMID: 6386993

DOI: 10.1111/1523-1747.ep12264100

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