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Expression of xenotropic murine leukemia viruses as cell surface glyco protein gp 70 in genetic crosses between strains dba 2 and c 57bl 6


, : Expression of xenotropic murine leukemia viruses as cell surface glyco protein gp 70 in genetic crosses between strains dba 2 and c 57bl 6. Journal of Experimental Medicine 149(5): 1183-1196

Flow microfluorometry was used to assess levels of xenotropic murine leukemia virus [MuLV] envelope-related cell-surface antigens (XenCSA) expressed on lymphocytes of mice derived from crosses between C57BL/6 (B6) and DBA/2 (D2); 24 recombinant inbred strains (BXD RIs) and 62 backcross mice were studied. XenCSA expression is affected by more than 1 gene but the predominant influence is exerted by a single semidominant gene apparently located on chromosome 4 at or in close proximity of the Fv-1 locus. Studies of spontaneous virus production in B6D2F1 .times. D2 mice suggest that this locus may also affect production by spleen cells of xenotropic MuLV registering in a fluorescent antibody assay of mink lung cells.

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