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Expression sv 40 gene a affects tubulin stability


, : Expression sv 40 gene a affects tubulin stability. Journal of Virology 32(1): 47-51

The stability of tubulins present in crude extracts of untransformed BALB/c-3T3 mouse fibroblasts, Chinese hamster lung cells and various of their SV-40 transformants was assessed by measurement of their individual colchicine-binding decay rates. In all cases studied the decays followed the kinetics of first-order reactions and rates were reduced at low temperatures and by vinblastine sulfate. Under all assay conditions, including different temperatures and protein concentrations, tubulins of normal cells decayed considerably faster than those of SV-40-transformed cells. Experiments performed with a number of Chinese hamster lung cell clones transformed with temperature-sensitive SV-40 gene A mutants showed a clear correlation between increased tubulin stability and the expression of gene A function. T-antigen, the viral gene A product, may affect tubulin.

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