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Extended blood collection period required to define distribution and elimination kinetics of propofol






British Journal of Clinical Pharmacology 26(2): 187-190

Extended blood collection period required to define distribution and elimination kinetics of propofol

The pharmacokinetics of propofol were investigated following bolus intravenous administration of 2-3 mg kg-1 of drug to eight surgical patients. Apparent elimination of half-life, volume of distribution and systemic blood clearance of propofol correlated strongly with the sampling period, which ranged from 8 to 52 h, depending on the time taken for the propofol concentration to reach the detection limit of the assay. In the three patients in whom the sampling period exceeded 42 h, apparent elimination half-life (55.6 h) and apparent volume of distribution (1370 1) greatly exceeded previously published estimates and systemic blood clearance (1020 ml m-1) was much less than previous estimates. This suggests that previous estimates were biased by the relatively short duration of blood collection in those studies (8 to 12 h).

Accession: 005432551

PMID: 3264711

DOI: 10.1111/j.1365-2125.1988.tb03386.x

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