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Extended monod kinetics for substrate, product, and cell inhibition


Biotechnology and Bioengineering 32(4): 430-447
Extended monod kinetics for substrate, product, and cell inhibition
A generalized form of monod kinetics is proposed to account for all kinds of product, cell, and substrate inhibition. This model assumes that there exists a critical inhibitor concentration above which cells cannot grow, and that the constants of the monod equation are functions of this limiting inhibitor concentration. Methods for evaluating the constants of this rate form are presented. Finally the proposed kientic form is compared with the available data in the literature, which unfortunately is very sparse. In all cases, this equation form fitted the data very well.

Accession: 005432632

PMID: 18587739

DOI: 10.1002/bit.260320404

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